This category includes factors that combine biological and environmental factors, such as congenital disorders or diseases in early life, that affect the development of the brain and higher mental functions. Disturbing interventions are cases in which biological and environmental factors interact to disrupt the development of executive functions. Common examples include hypoxia during childbirth (complicated childbirth), early brain infections, and malnutrition in early childhood. These factors can disrupt the normal development of the frontal lobes and their associated neural networks, affecting the ability to plan, organize activities, control impulses, and make decisions. Therefore, early therapeutic intervention is necessary to compensate for neurological disorders and prevent the development of learning and behavioral difficulties in the future.