A method of transmission of a genetic disease, in which one mutant gene from one of the parents is enough for the disease to manifest itself in a child. Main characteristics: inheritance occurs through autosomes, the trait manifests itself in each generation, the probability of inheritance is 50% if there is a mutant gene in one parent, if there is a mutant gene in both parents, the probability increases to 75%, the disease does not depend on gender. Examples of diseases include Marfan syndrome (connective tissue disorder manifested by lengthening of the limbs, heart and vision problems), Huntington’s chorea (progressive damage to the nervous system), polycystic kidney disease (the formation of multiple cysts in the kidneys), neurofibromatosis (a disease characterized by the formation of tumors of the nervous system).