The complex and interconnected set of factors that lead to the onset of physical symptoms of psychological origin cannot be fully explained by biological mechanisms alone, but rather by the constant interaction of mind, body, and environment. These causes are rooted in several interrelated levels, the first of which is psychological, where chronic stress, unresolved internal conflicts, anxiety and depression, as well as a lack of coping skills, play a fundamental role in the physiological changes that lead to the appearance of physical symptoms. At the neurohormonal level, an overactive autonomic nervous system and the release of stress hormones such as cortisol and adrenaline contribute to a weakened immune system and increased susceptibility to physical diseases such as cardiovascular, digestive, and skin. From a personality perspective, certain personality traits, such as a tendency to be emotionally suppressed, difficulty expressing feelings, or a tendency to be perfectionist and strict with themselves, are factors that increase people’s susceptibility to this type of disorder. Social and cultural factors also play an important role. Lack of social support, dysfunctional family relationships, or a stressful work environment can increase the likelihood of experiencing psychosomatic symptoms, while cultural beliefs about illness, self, and body affect how patients perceive and express their symptoms. The biological aspect cannot be ignored either, as some people may have a greater predisposition to physical reactions to psychological stress due to differences in neurological or endocrine structure. Consequently, the causes of psychosomatic disorders are not a single source, but rather the result of a dynamic interaction of psychological, neurological, physical, and social factors. This explains the diversity of their manifestations in different people and necessitates a holistic approach to their understanding, diagnosis and treatment.