the central concept of V. Frankl’s logotherapy, which describes the state of loss of meaning, characterized by a deep sense of inner emptiness and meaninglessness of existence, the collapse of value orientations, the lack of clear life goals, apathy, a decrease in activity, and a refusal to make life choices. Existential vacuum is not a pathology, but rather a challenge to the search for new meanings. An existential vacuum, according to logotherapy, can nevertheless lead to noogenic neurosis (see Noogenic neurosis in Chapter 2.1. Key Psychological Concepts in Clinical Psychology) and clinical symptoms.