psychoneurological hereditary disease. It occurs only in females with a frequency of one case per 10000-15000. The diagnosis is made, as a rule, at the age of 1.5-4 years on the basis of characteristic symptoms: the disintegration of speech and motor skills that have begun to form, peculiar movements of the hands, difficulties in eating, fixed gaze, forced laughter, etc. Children with this syndrome have pronounced mental retardation, which is significantly aggravated by emotional disorders.