The role of genetic predisposition is that some people are more susceptible to developing this type of disorder than others, which manifests itself in the form of physical symptoms caused by psychological factors. Recent research in behavioral genetics and psychosomatic medicine confirms that genes not only determine the occurrence of the disorder, but also contribute to the formation of the biological structure of the nervous, endocrine, and immune systems, causing various responses to psychological stress. For example, a family history of anxiety disorders, depression, or certain chronic illnesses may increase the likelihood of developing psychosomatic symptoms in offspring. This may be due to the transmission of certain patterns of neurohormonal regulation or excessive activation of the autonomic nervous system. Some studies also indicate that genetic variation in neurotransmitters such as serotonin and dopamine, or genes associated with the hypothalamic-pituitary-adrenal axis (HPA-axis), may contribute to increased sensitivity to stress and increased physical responses to it. However, the contribution of genetic factors is not seen as inevitable or absolute. Family environment, socialization patterns, early life experiences, and individual coping mechanisms all play a modulating role that can strengthen or weaken the influence of genetic predisposition. Accordingly, it can be said that the contribution of genetic factors to the occurrence of psychosomatic disorders is significant, but not the only one. They act in a complex interaction with psychological, social and environmental factors. This makes these disorders the result of an interconnected network of stimuli that cannot be explained by a single cause, but rather by the integration of a genetic pattern and acquired circumstances.