is based on the idea that the nervous, endocrine, and immune systems form an integrated network of vital interactions that are influenced by psychological, social, and biological factors. When a person is exposed to psychological stress or chronic negative emotions (anxiety, grief, or repressed anger), the brain stimulates the autonomic nervous system and triggers hormonal responses, primarily the production of cortisol and adrenaline. These hormones temporarily help the body cope with a stressful situation. However, their constant release for a long time weakens the effectiveness of immune cells, such as T liphocytes and B lymphocytes, and disrupts the activity of natural killer cells, reducing the body’s ability to fight infection and increasing susceptibility to disease or slowing recovery. What’s more, the immune dysfunction that results from these reactions affects not only the physical condition but also the psychological state by sending inflammatory signals to the brain, leading to symptoms such as fatigue, low energy, and mood swings. Thus, the theoretical framework suggests that the relationship between psychosomatic diseases and immunity is cyclical: stress and emotions affect the effectiveness of the immune system, and changes in immunity, in turn, contribute to changes in emotions and behavior. This concept corresponds to the biopsychosocial model, which considers disease not as the result of one isolated factor, but as a dynamic interaction of the psyche, organism and environment. This makes understanding the interaction of psychosomatics and immunity necessary for the development of comprehensive therapeutic and preventive strategies.