{"id":55097,"date":"2025-05-28T11:56:12","date_gmt":"2025-05-28T11:56:12","guid":{"rendered":"https:\/\/psychologydictionary.ae\/weight-loss-linked-to-specific-brain-cells-without-causing-nausea\/"},"modified":"2025-05-28T11:56:12","modified_gmt":"2025-05-28T11:56:12","slug":"weight-loss-linked-to-specific-brain-cells-without-causing-nausea","status":"publish","type":"post","link":"https:\/\/psychologydictionary.ae\/fr\/weight-loss-linked-to-specific-brain-cells-without-causing-nausea\/","title":{"rendered":"Weight Loss Linked to Specific Brain Cells \u2013 Without Causing Nausea"},"content":{"rendered":"\n<p>Researchers at the <strong>University of Gothenburg<\/strong> have identified a group of <strong>nerve cells in the brainstem<\/strong> that appear to be responsible for the positive effects of <strong>semaglutide<\/strong>, such as <strong>appetite suppression<\/strong> and <strong>fat loss<\/strong>, without triggering side effects like <strong>nausea<\/strong>.<\/p>\n\n\n\n<p>This breakthrough could lead to the development of more refined <strong>anti-obesity medications<\/strong>.<\/p>\n\n\n\n<p>Semaglutide, a member of the <strong>GLP-1R agonists<\/strong> family, has gained popularity for managing <strong>obesity<\/strong> and <strong>type 2 diabetes<\/strong>. While effective, it can cause <strong>unwanted side effects<\/strong>, including <strong>muscle loss<\/strong> and nausea.<\/p>\n\n\n\n<p>In a new study published in <strong>Cell Metabolism<\/strong>, scientists at <strong>Sahlgrenska Academy<\/strong> discovered that it&#8217;s possible to separate the neural pathways responsible for the drug\u2019s <strong>therapeutic benefits<\/strong> from those involved in <strong>adverse reactions<\/strong>.<\/p>\n\n\n\n<p>Using <strong>mice models<\/strong>, researchers identified which <strong>neurons were activated<\/strong> by semaglutide. When these neurons were stimulated, without giving the drug, mice showed <strong>reduced food intake<\/strong> and <strong>weight loss<\/strong>. When these same neurons were destroyed, semaglutide\u2019s effects on appetite significantly weakened, yet <strong>side effects persisted<\/strong>.<\/p>\n\n\n\n<p>\u201cThis strongly suggests that these particular neurons are essential for the <strong>weight-reducing<\/strong> and <strong>appetite-lowering<\/strong> properties of semaglutide\u201d said <strong>J\u00falia Teixidor-Deulofeu<\/strong>, lead author and PhD student.<\/p>\n\n\n\n<p>These neurons are located in the <strong>dorsal vagal complex<\/strong>, an area of the <strong>brainstem<\/strong> involved in regulating <strong>energy balance<\/strong>.<br>According to researcher <strong>Linda Engstr\u00f6m Ruud<\/strong>, the findings not only open the door to more <strong>targeted obesity treatments<\/strong> but also expand our understanding of how <strong>GLP-1-based drugs<\/strong> interact with the <strong>brain\u2019s neural circuits<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of Gothenburg have identified a group of nerve cells in the brainstem that appear to be responsible for the positive effects of semaglutide, such as appetite suppression and fat loss, without triggering side effects like nausea. This breakthrough could lead to the development of more refined anti-obesity medications. Semaglutide, a member [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":55093,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[223],"tags":[],"class_list":["post-55097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles-de-presse"],"_links":{"self":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/posts\/55097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/comments?post=55097"}],"version-history":[{"count":0,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/posts\/55097\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/media\/55093"}],"wp:attachment":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/media?parent=55097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/categories?post=55097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/tags?post=55097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}