{"id":55108,"date":"2025-05-29T08:18:03","date_gmt":"2025-05-29T08:18:03","guid":{"rendered":"https:\/\/psychologydictionary.ae\/new-study-shows-alzheimers-disease-affects-more-than-just-the-brain\/"},"modified":"2025-05-29T08:18:03","modified_gmt":"2025-05-29T08:18:03","slug":"new-study-shows-alzheimers-disease-affects-more-than-just-the-brain","status":"publish","type":"post","link":"https:\/\/psychologydictionary.ae\/fr\/new-study-shows-alzheimers-disease-affects-more-than-just-the-brain\/","title":{"rendered":"New Study Shows Alzheimer\u2019s Disease Affects More Than Just the Brain"},"content":{"rendered":"\n<p>Although <strong>Alzheimer\u2019s disease<\/strong> is commonly known as a condition that affects the brain, new research reveals that its impact extends to other organs throughout the body. In a groundbreaking study, scientists from <strong>Baylor College of Medicine<\/strong>, the <strong>Jan and Dan Duncan Neurological Research Institute<\/strong> at <strong>Texas Children\u2019s Hospital<\/strong>, and their partners, used <strong>fruit flies<\/strong> to explore the wider effects of Alzheimer\u2019s disease at the cellular level.<\/p>\n\n\n\n<p>Published in <em>Neuron<\/em>, the study introduces the <strong>Alzheimer\u2019s Disease Fly Cell Atlas<\/strong>, a detailed map of <strong>gene expression<\/strong> across <strong>219 different cell types<\/strong> found in both the heads and bodies of genetically modified fruit flies. These flies were engineered to produce either the <strong>A\u03b242<\/strong> or <strong>Tau proteins<\/strong>\u2014two major culprits in Alzheimer\u2019s disease, specifically in their neurons, thereby simulating the disease without affecting development.<\/p>\n\n\n\n<p>\u201cWe observed that expressing <strong>A\u03b242<\/strong> or <strong>Tau<\/strong> in neurons led to significant changes not only in the nervous system but also in other body tissues,\u201d explained <strong>Ye-Jin Park<\/strong>, co-first author and graduate student. Notably, <strong>A\u03b242<\/strong> caused marked damage to <strong>sensory neurons<\/strong> involved in <strong>smell<\/strong>, <strong>hearing<\/strong>, and <strong>vision<\/strong>, with specific damage to <strong>olfactory neurons<\/strong>, aligning with clinical signs of early Alzheimer\u2019s.<\/p>\n\n\n\n<p>In contrast, <strong>Tau protein<\/strong> expression produced widespread disruptions in <strong>peripheral organs<\/strong>, including <strong>altered fat metabolism<\/strong>, <strong>digestive issues<\/strong>, and <strong>reduced fertility<\/strong>. According to <strong>Dr. Tzu-Chiao Lu<\/strong>, co-first author and postdoctoral researcher, these effects closely resemble signs of <strong>accelerated aging<\/strong> and point to disrupted <strong>brain-body communication<\/strong>.<\/p>\n\n\n\n<p>\u201cThis comprehensive cell atlas gives us a new perspective on how <strong>Alzheimer \u2019s-associated proteins<\/strong> influence the body beyond the brain,\u201d said <strong>Dr. Hugo Bellen<\/strong>, co-corresponding author and chair in <strong>neurogenetics<\/strong> at Duncan NRI. \u201cIt opens new doors to discovering <strong>biomarkers<\/strong> and developing <strong>therapies<\/strong> that target Alzheimer\u2019s from a whole-body approach\u201d.<br>The resource is expected to aid researchers worldwide in studying the <strong>systemic effects of neurodegeneration<\/strong>, furthering understanding and potentially improving treatment options for patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although Alzheimer\u2019s disease is commonly known as a condition that affects the brain, new research reveals that its impact extends to other organs throughout the body. In a groundbreaking study, scientists from Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children\u2019s Hospital, and their partners, used fruit flies to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":55104,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[223],"tags":[],"class_list":["post-55108","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles-de-presse"],"_links":{"self":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/posts\/55108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/comments?post=55108"}],"version-history":[{"count":0,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/posts\/55108\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/media\/55104"}],"wp:attachment":[{"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/media?parent=55108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/categories?post=55108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/psychologydictionary.ae\/fr\/wp-json\/wp\/v2\/tags?post=55108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}